![]() ![]() First, it has transitioned from an illness defined by psychosis to one reflecting multiple symptom domains. Paralleling the advent of the second generation or “atypical” antipsychotics (SGAs) in the 1990s has been several important shifts in how schizophrenia is conceptualized. From this perspective, identification of biomarkers and/or endophenotypes permitting earlier diagnosis and intervention may serve to improve treatment efficacy as well as outcomes. Their onset, which can precede the first psychotic break, also means that treatments are delayed. The array and diversity of strategies currently under investigation highlight the lack of evidence-based treatments and our limited understanding regarding negative symptoms underlying etiology and pathophysiology. Strategies include use of atypical antipsychotics, ensuring the lowest possible antipsychotic dose that maintains control of positive symptoms (this can involve a shift from antipsychotic polypharmacy to monotherapy), possibly an antidepressant trial (given diagnostic uncertainty and the frequent use of these drugs in schizophrenia), and non-somatic interventions (e.g., cognitive behavioral therapy, CBT). Presently, clinicians will sometimes turn to interventions that are seen as more “benign” and in line with routine clinical practice. This is particularly problematic for individuals burdened with negative symptoms in the face of mild or absent positive symptoms. Level and quality of evidence vary considerably, but to this point, no specific treatment can be recommended. Multiple interventions have been the subject of investigation, to date, including numerous pharmacological strategies, brain stimulation, and non-somatic approaches. Efforts continue to better define and measure negative symptoms, distinguish their impact from that of other symptom domains, and establish effective treatments as well as trials to assess these. The negative symptoms can vary in length of time you experience them and the severity.Interest in the negative symptoms of schizophrenia has increased rapidly over the last several decades, paralleling a growing interest in functional, in addition to clinical, recovery, and evidence underscoring the importance negative symptoms play in the former. The way your illness affects you will depend on the type of schizophrenia that you have. Cognitive experiences – low attention span, memory problems, unable to absorb information, poor decision makingĪ diagnosis of schizophrenia doesn’t mean you have all of these symptoms.Becoming withdrawn – Not saying much, change in body language, lack of eye contact, less interested in usual hobbies and activities. ![]() You may switch topics without any obvious link Disorganised thinking – The things you say might not make sense to other people. ![]()
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